Peptide Research Blog
Articles on laboratory handling, analytical verification, evidence quality and regulatory labelling for peptide research materials.
These articles summarise published scientific literature for laboratory professionals. They are not medical advice and do not describe human or veterinary use. All materials supplied by Peptide Pilots are for controlled laboratory research only.
Growth Hormone Secretagogues Compared: Sermorelin, CJC-1295, Tesamorelin and Ipamorelin in the Literature
Four peptides are routinely grouped as 'growth hormone secretagogues', yet they act on two different receptors and rest on very different quality of evidence. Here is how the published literature separates them.
Comparative literatureGHRH analoguesEndocrinologyRead the articleRepair Peptides in Preclinical Models: What the BPC-157 and TB-500 Literature Does and Does Not Show
BPC-157 and TB-500 are the two peptides most often described as 'repair' compounds. Both rest almost entirely on rodent models, and both carry specific, documentable weaknesses in their evidence base.
Preclinical evidenceTissue modelsEvidence qualityRead the articleMitochondrial Research Compounds: MOTS-c, SS-31 and NAD+ in the Published Literature
Three very different molecules get filed under 'mitochondrial'. One is encoded in mitochondrial DNA, one binds an inner-membrane lipid, and one is a redox cofactor. The distinctions matter when reading their studies.
Mitochondrial biologyComparative literatureBioenergeticsRead the articleMelanocortin Receptor Peptides: How the PT-141 and Melanotan II Literature Differs
Both peptides derive from the same melanocortin family, but one carries a completed regulatory trial programme and the other is defined mainly by case-report literature. Selectivity explains much of the gap.
Melanocortin systemReceptor selectivitySafety literatureRead the articleReading a Regional Literature: Semax, Selank and DSIP Research in Context
Three neuropeptides share an unusual research profile: substantial published output concentrated in one region, limited independent replication, and endpoints that are hard to measure objectively.
NeuropeptidesEvidence qualityPublication patternsRead the articleAnti-inflammatory and Matrix Peptides: GHK-Cu, KPV and Thymosin Alpha-1 Compared
Copper co-ordination, a three-residue alpha-MSH fragment and a 28-residue immune peptide sit in the same informal category. Their mechanisms, and the strength of their published records, have little in common.
ImmunologyMatrix biologyComparative literatureRead the articleWhy 'Research Use Only' Labelling Exists, and What It Means for a Laboratory
'For laboratory research use only' is not marketing language — it reflects a specific regulatory status. Here is what that status means, where it comes from, and what it requires of a laboratory that receives the material.
RegulatoryLaboratory complianceLabellingRead the articleThe Incretin Receptor Literature at a Glance: GLP-1, GIP and Glucagon Receptor Pharmacology
Single, dual and triple incretin-receptor agonists are among the most extensively studied peptide classes in the literature. This survey maps the receptor pharmacology and flags where the evidence base is strongest and weakest.
Receptor pharmacologyIncretinsLiterature reviewRead the articleLyophilisation, Reconstitution and Stability: Variables That Affect Peptide Research Material
Freeze-drying is chosen for a reason, and reconstitution is not a trivial step. Here is what the literature says about the variables that determine how long a peptide solution remains suitable for use in an experiment.
Laboratory handlingStabilityLyophilisationRead the articleReading Preclinical Evidence: In-Vitro, Animal and Human Study Design Compared
A receptor-binding result in a cell line, a metabolic finding in a rodent, and an endpoint from a randomised human trial are three fundamentally different kinds of evidence. Here is how to tell them apart and weigh them appropriately.
Study designEvidence qualityMethodologyRead the articleHow Peptide Purity Is Verified: HPLC, Mass Spectrometry and What a COA Actually Shows
Purity numbers on a peptide vial are not self-explanatory. Here is what RP-HPLC and mass spectrometry actually measure, and how to read the certificate of analysis that should accompany every lot.
Analytical methodsQuality documentationHPLCRead the article